# GRCh38 SNVs, all review statuses
consequence	P/LP	B/LB	VUS	conflicting	other	all	P/LP share of class	share of all P/LP
synonymous	830	714264	21737	29559	22834	789224	0.11%	0.42%
missense	72225	145894	2158309	120733	61066	2558227	2.82%	36.60%
nonsense	76202	632	11953	2193	8273	99253	76.78%	38.61%
other	48096	480064	118570	22078	153054	821862	5.85%	24.37%
total P/LP	197353

# GRCh38 SNVs, reviewed (criteria provided)
consequence	P/LP	B/LB	VUS	conflicting	other	all	P/LP share of class	share of all P/LP
synonymous	692	697838	19068	29540	22392	769530	0.09%	0.39%
missense	61699	140087	2135389	120529	56459	2514163	2.45%	34.40%
nonsense	72133	543	11327	2179	7800	93982	76.75%	40.21%
other	44855	472220	114928	22031	149154	803188	5.58%	25.01%
total P/LP	179379

# genes with most P/LP synonymous SNVs
COL7A1	13
NF1	13
MLH1	8
ATM	7
LMNA	7
TSC2	7
TP53	7
PDHA1	7
ABCA4	7
LDLR	6
CFTR	6
BRCA2	6
RYR1	6
SCN1A	6
USH2A	5
F8	5
RB1	5
FBN1	5
MYO15A	5
KMT2D	5
CDH1	5
NIPBL	5
GAA	5
NEB	5
APC	5