case coding_share_of_comparison coding_share_of_hits r F source As published 2.0% 4.9% 0.408 29.8% functional-dna: 2% coding, Maurano 2012 Fig. S1B 4.9% Published inputs, exact ratio 2.0% 4.9% 0.396 29.0% same inputs, r = ((1-h)/(1-g))/(h/g) Maurano with its own coding size 1.0% 4.9% 0.204 15.1% hg19 CCDS 32.28 Mb / 3.1 Gb = 1.04% (our count) 2026 Catalog vs genome 1.3% 3.6% 0.355 25.8% our count: 3.63% of 327,456 catalog variants in CDS 2026 Catalog vs common SNPs 0.8% 3.6% 0.214 15.9% our count: 0.80% of 12.8 M common SNVs in CDS Catalog to 2011 vs common SNPs 0.8% 8.1% 0.091 7.3% our count: 8.14% of 2,900 variants in CDS Heritability, Finucane 2015 1.5% 10.4% 0.131 10.1% coding 1.5% of SNPs, 10.4% of SNP-heritability (9-trait meta, Table S3) Heritability, Gusev 2014 (imputed) 0.6% 8.0% 0.067 5.6% coding explained 8% of h2 at 13.8-fold enrichment (11 diseases) Fine-mapped, Farh 2015 (autoimmune) 4.0% 14.0% 0.256 18.9% 14% of PICS causal SNPs protein-coding vs 4% of random SNPs Fine-mapped, Huang 2017 (IBD, PP>0.5) 1.6% 28.9% 0.040 3.8% 13 of 45 nonsynonymous, 18-fold over random variants in the regions Fine-mapped, Weissbrod 2020 (UKB, PIP>0.95) 0.8% 31.0% 0.018 2.2% 31% of 2,225 PIP>0.95 SNPs coding; common-SNP coding share 0.80% as background